Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides
نویسندگان
چکیده
منابع مشابه
Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides.
We report the synthesis of a 5-formyl-2'-deoxyuridine (5fU) phosphoramidite and the preparation of oligonucleotides comprising all known, naturally observed eukaryotic thymidine modifications. Biophysical characterization of the synthetic oligonucleotides indicates that 5fU, but not the other T-derivatives, can alter DNA structures.
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2017
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c6cc08670e